[Isotope-prod] Comments on Ga activation rates

[Sundaresan Gobalakrishnan]

I agree. Also, there will be instances where repetitive doses may be required for a single patient.

Best regards,
Sundaresan

On Jan 9, 2016 13:36, "Wells, Douglas P." <Doug.Wells at sdsmt.edu> wrote:

Thanks Hari and George:



For human drug trials, which the folks are VCU are far better sources of knowledge than I, I’ve been told that an approximate typical dose is 10 mCi.  If there are of order 100 people in such trials, they’d need of order Curies for each administration of dose.



Thanks---D



From: Isotope-prod [mailto:isotope-prod-bounces at jlab.org] On Behalf Of Hari Areti
Sent: Saturday, January 09, 2016 11:29 AM
To: Neil George
Cc: isotope-prod at jlab.org
Subject: Re: [Isotope-prod] Comments on Ga activation rates



Dear George,

As advised by Doug, I read through Bindu's thesis. If his predictions hold,

the demand is in Curies. Doug is the best source for such information.

-H



________________________________

From: "Neil George" <neil at jlab.org<mailto:neil at jlab.org>>
To: isotope-prod at jlab.org<mailto:isotope-prod at jlab.org>
Sent: Saturday, January 9, 2016 11:04:57 AM
Subject: Re: [Isotope-prod] Comments on Ga activation rates



George
I think this is great and I like the idea of the small mass (especially
if we are starting with the ultrapure target).
My only question is: what is the potential market for this isotope?
There is no point in making 200 mCi if you can only sell 10 mCi at a
given point in time.   I thought I had asked this question before and
gotten an answer around 10 mCi but maybe I didn't state it clearly.
If you had 200 mCi to sell would there be enough buyers?
George


On 1/8/2016 5:10 PM, George Kharashvili wrote:
> Dear collaboration members,
>
> I did some modeling to include activation rates of various targets mentioned yesterday. Here are some conclusions:
> - There is no good reason to increase radiator thickness - 1 to 1.5 mm tungsten is optimal.
> - Activation rates presented in the proposal (17 mCi/h/kW at 40 MeV) were calculated for what can be assumed an infinite natural Ga target. Replacing it with other targets results in the following:
> 3cm diameter, 5 cm long cylinder (m=210g) - 10 mCi/h/50kW
> 3cm diameter, 10 cm long cylinder (m=420g) - 12 mCi/h/50kW
> Truncated cone D1=1.5cm D2=10.6cm H=6.5cm (m=1310g) (currently in the proposal) - 13 mCi/h/50kW
> Truncated cone D1=2cm D2=6cm H=10cm (m=800g) - 12 mCi/h/50kW
> Truncated cone D1=1.5cm D2=15.5cm H=10cm (m=4110g) - 15 mCi/h/50kW
>
> If we take the smallest of these targets (~200g) and assume 20 hours of 50 kW beam (ignoring decay of Cu-67), we should produce ~200 mCi of Cu-67. This is roughly 260 nanograms, or 1.3 ppb of Cu-67 in our 200 g natural Ga target, which is greater than the 0.5 ppb of Cu content of 99.9999% Ga sample.
>
> I hope this information is useful for the proposal.
>
> --
> George Kharashvili
> Jefferson Lab Radiation Control
> 757-269-6435
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> Isotope-prod mailing list
> Isotope-prod at jlab.org<mailto:Isotope-prod at jlab.org>
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