[Isotope-prod] [EXTERNAL] Notes for isotope target working session

[Jamal Zweit]

All,
Sorry we could not be at the meeting yesterday. I would like to share these notes with you:

1. Solution targets per se is becoming a desirable approach even for cyclotron irradiation for isotope production.  Will emphasize this novelty for Cu-67 production from liquid Ga.
2. Recent research (see attached) demonstrates PET isotope production from liquid targets, ala, 18O(p,n)18F cyclotron production of 18F. For example, production of 68Ge from proton irradiation of liquid Ga target (see attached). These will be good references for our application, also they describe target transfer mechanisms which we can learn from.  The same approach is also being considered for the production of other isotopes, including using 200MeV protons (e.g. at BLIP)
3. Ga oxide has also been investigated, but this must be encapsulated in high heat conductivity material, such as Nb. Nb is a conventional encapsulation material, due to its chemical  resistance against oxidation in hot liquid Ga. Along with W, Nb, Mo and Ta can also be considered as liquid Ga target inserts. Non-interaction of the insert with Ga and Cu is an important requirement.

The attached material is useful for us, and we could discuss it in the next meeting, but it gives us a good source of feasibility, albeit it is based on proton charged particle irradiations in cyclotrons.

I hope this is helpful,

Jamal



Jamal Zweit, PhD, DSc
Professor of Radiology, 
Affiliate Professor of Radiation Oncology; Pathology; Biochemistry & Molecular Biology; and Chemistry
Director, Center for Molecular Imaging
Department of Radiology
School of Medicine
Virginia Commonwealth University
1101 E. Marshall Street
Sanger Hall, Room 8-022
PO Box 980031
Richmond, VA 23298-0031
(804) 628 2791

-----Original Message-----
From: George Neil [mailto:neil at jlab.org] 
Sent: Thursday, May 26, 2016 11:40 AM
To: Sundaresan Gobalakrishnan <sundaresan.gobalakrishnan at vcuhealth.org>; isotope production <isotope-prod at jlab.org>; George Biallas <BIALLAS at jlab.org>; Jamal Zweit <jamal.zweit at vcuhealth.org>
Subject: Re: [EXTERNAL] [Isotope-prod] Notes for isotope target working session

No problem!  We had a very useful session and got a lot of ideas and questions on the table.

George



On 5/26/2016 11:21 AM, Sundaresan Gobalakrishnan wrote:
> Dear George,
>
> Apologies for not being able to join yesterday. There was an internal deadline for a grant application and so we were quite tied up.
>
> Many thanks for the notes that you sent. Will be helpful for working out the purification steps from our end.
>
> Best regards,
> Sundaresan
> _____________________________________________
> Sundaresan Gobalakrishnan, PhD
> Assistant Professor
> Center for Molecular Imaging, Department of Radiology Virginia 
> Commonwealth University, Richmond, VA – 23298
> Phone: 804-628-9165; Fax: 804-628-0223
> E-mail: sundaresan.gobalakrishnan at vcuhealth.org
>
>
>
>
>
>
> -----Original Message-----
> From: Isotope-prod [mailto:isotope-prod-bounces at jlab.org] On Behalf Of 
> George Neil
> Sent: Thursday, May 26, 2016 8:45 AM
> To: isotope production <isotope-prod at jlab.org>; George Biallas 
> <BIALLAS at jlab.org>
> Subject: [EXTERNAL] [Isotope-prod] Notes for isotope target working 
> session
>
> Thanks to everyone who participated in a good discussion of the issues
> and ideas for isotope target design.   I've attached my notes which are
> somewhat incomplete so if there are topics/ideas which you feel strongly
> about that I have missed please reply to all with your comments.   I
> don't want to forestall the possibility of introducing any good ideas at this point.
>
> George
>
>

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