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OK. It seems like we can easily use the full capability. It will
certainly lower the price per dose so that is good too. Sounds like
the story holds together.<br>
George<br>
<br>
<br>
<br>
<div class="moz-cite-prefix">On 1/9/2016 1:36 PM, Wells, Douglas P.
wrote:<br>
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<p class="MsoNormal"><span
style="font-size:11.0pt;font-family:"Calibri","sans-serif";color:#1F497D">Thanks
Hari and George:<o:p></o:p></span></p>
<p class="MsoNormal"><span
style="font-size:11.0pt;font-family:"Calibri","sans-serif";color:#1F497D"><o:p> </o:p></span></p>
<p class="MsoNormal"><span
style="font-size:11.0pt;font-family:"Calibri","sans-serif";color:#1F497D">For
human drug trials, which the folks are VCU are far better
sources of knowledge than I, I’ve been told that an
approximate typical dose is 10 mCi. If there are of order
100 people in such trials, they’d need of order Curies for
each administration of dose.<o:p></o:p></span></p>
<p class="MsoNormal"><span
style="font-size:11.0pt;font-family:"Calibri","sans-serif";color:#1F497D"><o:p> </o:p></span></p>
<p class="MsoNormal"><span
style="font-size:11.0pt;font-family:"Calibri","sans-serif";color:#1F497D">Thanks---D<o:p></o:p></span></p>
<p class="MsoNormal"><a moz-do-not-send="true"
name="_MailEndCompose"><span
style="font-size:11.0pt;font-family:"Calibri","sans-serif";color:#1F497D"><o:p> </o:p></span></a></p>
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<p class="MsoNormal"><b><span
style="font-size:10.0pt;font-family:"Tahoma","sans-serif"">From:</span></b><span
style="font-size:10.0pt;font-family:"Tahoma","sans-serif"">
Isotope-prod [<a class="moz-txt-link-freetext" href="mailto:isotope-prod-bounces@jlab.org">mailto:isotope-prod-bounces@jlab.org</a>]
<b>On Behalf Of </b>Hari Areti<br>
<b>Sent:</b> Saturday, January 09, 2016 11:29 AM<br>
<b>To:</b> Neil George<br>
<b>Cc:</b> <a class="moz-txt-link-abbreviated" href="mailto:isotope-prod@jlab.org">isotope-prod@jlab.org</a><br>
<b>Subject:</b> Re: [Isotope-prod] Comments on Ga
activation rates<o:p></o:p></span></p>
</div>
</div>
<p class="MsoNormal"><o:p> </o:p></p>
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<div>
<p class="MsoNormal"><span
style="font-family:"Arial","sans-serif";color:black">Dear
George,<o:p></o:p></span></p>
</div>
<div>
<p class="MsoNormal"><span
style="font-family:"Arial","sans-serif";color:black">As
advised by Doug, I read through Bindu's thesis. If his
predictions hold,<o:p></o:p></span></p>
</div>
<div>
<p class="MsoNormal"><span
style="font-family:"Arial","sans-serif";color:black">the
demand is in Curies. Doug is the best source for such
information.<o:p></o:p></span></p>
</div>
<div>
<p class="MsoNormal"><span
style="font-family:"Arial","sans-serif";color:black">-H<o:p></o:p></span></p>
</div>
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<p class="MsoNormal"><span
style="font-family:"Arial","sans-serif";color:black"><o:p> </o:p></span></p>
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<p class="MsoNormal"><b><span
style="font-family:"Arial","sans-serif";color:black">From:
</span></b><span
style="font-family:"Arial","sans-serif";color:black">"Neil
George" <<a moz-do-not-send="true"
href="mailto:neil@jlab.org">neil@jlab.org</a>><br>
<b>To: </b><a moz-do-not-send="true"
href="mailto:isotope-prod@jlab.org">isotope-prod@jlab.org</a><br>
<b>Sent: </b>Saturday, January 9, 2016 11:04:57 AM<br>
<b>Subject: </b>Re: [Isotope-prod] Comments on Ga
activation rates<o:p></o:p></span></p>
</div>
<div>
<p class="MsoNormal"><span
style="font-family:"Arial","sans-serif";color:black"><o:p> </o:p></span></p>
</div>
<div>
<p class="MsoNormal"><span
style="font-family:"Arial","sans-serif";color:black">George<br>
I think this is great and I like the idea of the small
mass (especially <br>
if we are starting with the ultrapure target).<br>
My only question is: what is the potential market for
this isotope? <br>
There is no point in making 200 mCi if you can only sell
10 mCi at a <br>
given point in time. I thought I had asked this
question before and <br>
gotten an answer around 10 mCi but maybe I didn't state
it clearly.<br>
If you had 200 mCi to sell would there be enough buyers?<br>
George<br>
<br>
<br>
On 1/8/2016 5:10 PM, George Kharashvili wrote:<br>
> Dear collaboration members,<br>
><br>
> I did some modeling to include activation rates of
various targets mentioned yesterday. Here are some
conclusions:<br>
> - There is no good reason to increase radiator
thickness - 1 to 1.5 mm tungsten is optimal.<br>
> - Activation rates presented in the proposal (17
mCi/h/kW at 40 MeV) were calculated for what can be
assumed an infinite natural Ga target. Replacing it with
other targets results in the following:<br>
> 3cm diameter, 5 cm long cylinder (m=210g) - 10
mCi/h/50kW<br>
> 3cm diameter, 10 cm long cylinder (m=420g) - 12
mCi/h/50kW<br>
> Truncated cone D1=1.5cm D2=10.6cm H=6.5cm (m=1310g)
(currently in the proposal) - 13 mCi/h/50kW<br>
> Truncated cone D1=2cm D2=6cm H=10cm (m=800g) - 12
mCi/h/50kW<br>
> Truncated cone D1=1.5cm D2=15.5cm H=10cm (m=4110g)
- 15 mCi/h/50kW<br>
><br>
> If we take the smallest of these targets (~200g)
and assume 20 hours of 50 kW beam (ignoring decay of
Cu-67), we should produce ~200 mCi of Cu-67. This is
roughly 260 nanograms, or 1.3 ppb of Cu-67 in our 200 g
natural Ga target, which is greater than the 0.5 ppb of
Cu content of 99.9999% Ga sample.<br>
><br>
> I hope this information is useful for the proposal.<br>
><br>
> --<br>
> George Kharashvili<br>
> Jefferson Lab Radiation Control<br>
> 757-269-6435<br>
> _______________________________________________<br>
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href="https://mailman.jlab.org/mailman/listinfo/isotope-prod">https://mailman.jlab.org/mailman/listinfo/isotope-prod</a><br>
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