[Isotope-prod] Reminder VCU Talk Monday 11:30 CC F224-5

[Wells, Douglas P.]

I assume by “toxicity” you mean “dilution”?   Because dilution of the good-stuff (in this case, 67Cu) is usually the limiting factor toward utility.   I should start by saying that the answer that I got from City of Hope Hospital researchers in California may depend greatly on the kind of research one is doing.   For some of their research they wanted Specific Activity (SA) of approximately 20 Ci/g, while for other tissue-culture research they could live with an SA of 1 Ci/g.    These correspond to very roughly 1 67Cu atom per 10,000 – 100,000 other Cu atoms.

That sounds like a lot of stable Cu atoms.    Except EVERYTHING has Cu in it: your skin, the air, plastics, glassware, purified and enriched Ga targets, purified and Zn targets, water, everything.

And therein lies the challenge.   For people have known how to make 67Cu for a long time, and BNL has invested a considerable sum producing it, only to find that the final product was inconsistent in purity/SA quality and, therefore, unusable for large-scale research trials.

D



From: Isotope-prod [mailto:isotope-prod-bounces at jlab.org] On Behalf Of Pavel Degtiarenko
Sent: Monday, September 28, 2015 4:29 PM
To: isotope-prod at jlab.org
Subject: Re: [Isotope-prod] Reminder VCU Talk Monday 11:30 CC F224-5

Dear All,

Could anyone clarify to us the situation with the toxicity of Copper: what ratio of (Cu-63 + Cu-65) to Cu-67 atoms in the final product is too big, such that the product would become unacceptable.

We understand now that by making Cu-67 from Gallium, for example, the ratio could be done less than an order of few times, or even less than one. In case of Zinc target the ratio would be worse because the stable isotopes of Zinc are closer in both Z and A to stable Cu-63 and Cu-65 than the isotopes of Gallium. I guess this ratio would be enormous if Cu-67 is produced in Copper with double neutron captures on reactors.

In our conditions, without the initial Copper in the target, the ratio should stay rather limited, with the Gallium target having some advantage in that respect. Would that be good enough? What would be a hard limit on the ratio?

Best regards,
Pavel



On 9/28/2015 5:12 PM, Sundaresan Gobalakrishnan wrote:

Actinium-225 and Copper-67 are the first two products that we could initially try, due to their high medical relevance and in-house availability of related technologies for in vivo delivery in living subjects (in mice for now).

Best regards,
Sundaresan
On Sep 28, 2015 4:46 PM, "Wells, Douglas P." <Doug.Wells at sdsmt.edu><mailto:Doug.Wells at sdsmt.edu> wrote:
I wonder if, in the meantime - before the phone call is held, VCU can share with us the list of nuclear species that they are interested in?    We (SDSM&T) could look into photo-production of them if we knew what species are on their mind.

Thanks---D

-----Original Message-----
From: Isotope-prod [mailto:isotope-prod-bounces at jlab.org] On Behalf Of Sundaresan Gobalakrishnan
Sent: Monday, September 28, 2015 7:38 AM
To: George Neil; isotope production
Subject: Re: [Isotope-prod] Reminder VCU Talk Monday 11:30 CC F224-5

Dear George and All,

I regret to inform you that due to an emergency in Dr. Zweit's family, he will not be able to come and present his ideas at JLab today.

Once he returns to work, he will get in touch with you to reschedule his presentation.

Very sorry about any inconvenience this may cause.

Best regards,
Sundaresan

_____________________________________________
Sundaresan Gobalakrishnan, PhD
Assistant Professor
Center for Molecular Imaging, Department of Radiology Virginia Commonwealth University, Richmond, VA - 23298
Phone: 804-628-9165; Fax: 804-628-0223
E-mail: sundaresan.gobalakrishnan at vcuhealth.org<mailto:sundaresan.gobalakrishnan at vcuhealth.org>



-----Original Message-----
From: Isotope-prod [mailto:isotope-prod-bounces at jlab.org] On Behalf Of George Neil
Sent: Friday, September 25, 2015 11:39 AM
To: isotope production <isotope-prod at jlab.org><mailto:isotope-prod at jlab.org>
Subject: [Isotope-prod] Reminder VCU Talk Monday 11:30 CC F224-5


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