[Isotope-prod] Reminder VCU Talk Monday 11:30 CC F224-5
Pavel Degtiarenko
pavel at jlab.org
Mon Sep 28 22:42:50 EDT 2015
Thank you Douglas,
The practical conclusion for us would be then that we do not worry about
other Cu isotopes, including 63Cu and 65Cu produced along with 67Cu,
because there will always be much larger source of those in the target
originally, and during the cycle of separation from different sources.
The dilution then becomes a characteristic to the whole process, and the
processes should be optimized to achieve maximum SA. Would it help to
run the non-irradiated target material through the separation process
first several times to reach the equilibrium between Cu removal from the
target material, and new Cu contamination coming back to the target
material at the other stages of the process?
Did anyone consider the process of Gallium distillation at 2400C
(boiling temp of Ga) with Ga evaporating from the mixture, and Cu
staying (boils at 2562C).
Best regards,
Pavel
On 9/28/2015 6:47 PM, Wells, Douglas P. wrote:
>
> I assume by “toxicity” you mean “dilution”? Because dilution of the
> good-stuff (in this case, 67Cu) is usually the limiting factor toward
> utility. I should start by saying that the answer that I got from
> City of Hope Hospital researchers in California may depend greatly on
> the kind of research one is doing. For some of their research they
> wanted Specific Activity (SA) of approximately 20 Ci/g, while for
> other tissue-culture research they could live with an SA of 1 Ci/g.
> These correspond to very roughly 1 67Cu atom per 10,000 – 100,000
> other Cu atoms.
>
> That sounds like a lot of stable Cu atoms. Except EVERYTHING has Cu
> in it: your skin, the air, plastics, glassware, purified and enriched
> Ga targets, purified and Zn targets, water, everything.
>
> And therein lies the challenge. For people have known how to make
> 67Cu for a long time, and BNL has invested a considerable sum
> producing it, only to find that the final product was inconsistent in
> purity/SA quality and, therefore, unusable for large-scale research
> trials.
>
> D
>
> *From:*Isotope-prod [mailto:isotope-prod-bounces at jlab.org] *On Behalf
> Of *Pavel Degtiarenko
> *Sent:* Monday, September 28, 2015 4:29 PM
> *To:* isotope-prod at jlab.org
> *Subject:* Re: [Isotope-prod] Reminder VCU Talk Monday 11:30 CC F224-5
>
> Dear All,
>
> Could anyone clarify to us the situation with the toxicity of Copper:
> what ratio of (Cu-63 + Cu-65) to Cu-67 atoms in the final product is
> too big, such that the product would become unacceptable.
>
> We understand now that by making Cu-67 from Gallium, for example, the
> ratio could be done less than an order of few times, or even less than
> one. In case of Zinc target the ratio would be worse because the
> stable isotopes of Zinc are closer in both Z and A to stable Cu-63 and
> Cu-65 than the isotopes of Gallium. I guess this ratio would be
> enormous if Cu-67 is produced in Copper with double neutron captures
> on reactors.
>
> In our conditions, without the initial Copper in the target, the ratio
> should stay rather limited, with the Gallium target having some
> advantage in that respect. Would that be good enough? What would be a
> hard limit on the ratio?
>
> Best regards,
> Pavel
>
>
>
> On 9/28/2015 5:12 PM, Sundaresan Gobalakrishnan wrote:
>
> Actinium-225 and Copper-67 are the first two products that we
> could initially try, due to their high medical relevance and
> in-house availability of related technologies for in vivo delivery
> in living subjects (in mice for now).
>
> Best regards,
> Sundaresan
>
> On Sep 28, 2015 4:46 PM, "Wells, Douglas P."
> <Doug.Wells at sdsmt.edu> <mailto:Doug.Wells at sdsmt.edu> wrote:
>
> I wonder if, in the meantime - before the phone call is held, VCU
> can share with us the list of nuclear species that they are
> interested in? We (SDSM&T) could look into photo-production of
> them if we knew what species are on their mind.
>
> Thanks---D
>
> -----Original Message-----
> From: Isotope-prod [mailto:isotope-prod-bounces at jlab.org] On
> Behalf Of Sundaresan Gobalakrishnan
> Sent: Monday, September 28, 2015 7:38 AM
> To: George Neil; isotope production
> Subject: Re: [Isotope-prod] Reminder VCU Talk Monday 11:30 CC F224-5
>
> Dear George and All,
>
> I regret to inform you that due to an emergency in Dr. Zweit's
> family, he will not be able to come and present his ideas at JLab
> today.
>
> Once he returns to work, he will get in touch with you to
> reschedule his presentation.
>
> Very sorry about any inconvenience this may cause.
>
> Best regards,
> Sundaresan
>
> _____________________________________________
> Sundaresan Gobalakrishnan, PhD
> Assistant Professor
> Center for Molecular Imaging, Department of Radiology Virginia
> Commonwealth University, Richmond, VA - 23298
> Phone: 804-628-9165; Fax: 804-628-0223
> E-mail: sundaresan.gobalakrishnan at vcuhealth.org
> <mailto:sundaresan.gobalakrishnan at vcuhealth.org>
>
>
>
> -----Original Message-----
> From: Isotope-prod [mailto:isotope-prod-bounces at jlab.org] On
> Behalf Of George Neil
> Sent: Friday, September 25, 2015 11:39 AM
> To: isotope production <isotope-prod at jlab.org>
> <mailto:isotope-prod at jlab.org>
> Subject: [Isotope-prod] Reminder VCU Talk Monday 11:30 CC F224-5
>
>
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